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FIGURE 5 Finally, Ang I is converted to either angiotensin II (Ang II), which has profibrotic and proinflammatory effects, or Ang (1-7), which displays the opposite antifibrotic effects

There are no serious adverse events, including skin changes, ulcerations, hypoesthesia, or diminished rigidity

A recent systematic review and meta-analysis confirmed that tirzepatide reduces both hsCRP and IL-6 compared to placebo