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Inhibiting macrophage-capping protein suppresses UFM1-mediated pirin modification, which downregulates GPX4 transcription and promotes HMGB1 cytosolic translocation, ultimately triggering ferroptosis and rapid release of this damage-associated molecular pattern (91)

Transcriptomic analysis, 4,192 genes

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While this interaction creates therapeutic potential, it also introduces risk if dosing, sourcing, or medical oversight is inadequate