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Statistical methods A linear mixed-effects model for repeated measures was used for the primary outcome, Glx/tNAA change from baseline

Chemical Structure and IP Portfolio VCT220 structure (free acid CAS: 2784590-83-4) features a benzimidazole-6-carboxylic acid core, an (S)-oxetan-2-ylaminomethyl group at N1, and a piperidine-methyl linker at C2 - elements shared with Pfizer's danuglipron (discontinued) and Hengrui/Kailera Therapeutics 's HRS-7535 (safiglipron) - connected to a 4-chloro-2-fluorobenzyl diaryl ether tail

We next used membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) to cleave the ectodomain of the IR in BMECs to construct a model of cells lacking the ectodomain of IR 24

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