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The lack of functional GSTU13 resulted in enhanced disease susceptibility toward several fungal pathogens including Erysiphe pisi, Colletotrichum gloeosporioides , and Plectosphaerella cucumerina (Pislewska-Bednarek et al., 2018)

A 2025 study published in JAMA Network Open found that most patients with obesity discontinue GLP-1 therapy within a year, particularly those without type 2 diabetes 1

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Four distinct areas of the lower face typically show the most noticeable changes after GLP-1-induced weight loss: Jowl formation Skin and soft tissue descend below the jawline border, disrupting the smooth jaw contour Pre-jowl sulcus Hollows develop on either side of the chin, creating a stepped appearance along the jaw Marionette lines Deep creases form from mouth corners to the chin as volume loss allows tissue descent Submental changes The area under the chin may appear loose or develop banding as platysma muscle becomes more visible What Are the Best Non-Surgical Treatments for Jawline Support in 2026

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