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10 used a target trial emulation framework with electronic health record (EHR) data from over one million DM2 patients and reported that semaglutide was associated with a significantly reduced risk of first-time AD diagnosis, outperforming seven other antidiabetic drug classes, including metformin 10

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Hence, further research is still needed to understand the most important mechanisms involved in GLP-1RA-mediated stroke protection specifically in the human diabetic brain and to connect the described experimental studies to clinical stroke