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Recent studies show that GLP-1(936) can activate the inhibitory G protein (Gi/o), leading to the translocation of secretory granules (SG) beneath the cell membrane, thereby inhibiting glucagon secretion

Drug repurposing of ACT001 to discover novel promising sulfide prodrugs with improved safety and potent activity for neutrophil-mediated antifungal immunotherapy

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CD4 + T cells from RA patients demonstrate decreased expression of the glycolytic rate-limiting enzyme PFKFB3 compared with healthy donor PBMCs, resulting in diminished pyruvate and ATP production (149)