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A group from California Institute of Technology (Caltech) has utilized a multivalent engineered protein domain called SpyCatcher to fuse antigens to virus-like particles

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Conclusions and perspectives A major challenge of developing vaccines against variable viruses, such as coronaviruses, is the difficulty in inducing immunity that cross-recognizes and protects against the full spectrum of possible viral variants while also limiting the opportunity for immune escape

Second, they indicate minimal risk of allergic or hypersensitivity reactions, which can occur when immune responses develop against therapeutic peptides

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