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Cox HD, et al
Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trial
On the contrary, their combined effect in normal hepatocytes showed a collapsed sub G1 area, similar to the one of untreated cells, denoting lesser cytotoxicity
QMP substitutions compensate for decreased FcRn binding caused by L585 cleavage The three amino acid substitutions introduced in DIII of human albumin, QMP, greatly improve its pH-dependent binding to human FcRn (Fig
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