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Mass Spectrometry analysis was performed with an Orbitrap Fusion mass spectrometer (Thermo Fisher Scientific) with a nanospray ion source and an EASY-nLC 1000 system (Thermo Fisher Scientific)

Under normal conditions, Nrf2 is anchored in the cell cytoplasm by a repressor protein called Keap1

Blinding was assessed by asking participants which order of placebo and naltrexone pretreatments they believed they received after the final dosing session at the day 1 follow-up, with Dont know a valid option

Mucosal Immunol 6(2):379392

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