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GLP-1 medications essentially act like a supercharged version of this natural hormone

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NSAIDs like ibuprofen, which some patients take regularly for pain or headaches during the adjustment period, cause sodium and water retention through their effects on kidney prostaglandins

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Unknown Long-Term Safety Profile: A short plasma half-life of under 30 minutes in rats and dogs, alongside low bioavailability after intramuscular administration, raises critical questions about what occurs with higher, repeated, or long-term exposures in humans