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In the SURPASS-2 trial (published in The New England Journal of Medicine in 2021), tirzepatide at 5, 10, and 15 mg was compared with semaglutide 1 mg in 1,879 adults with type 2 diabetes on metformin over 40 weeks

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Beyond their established metabolic effects, emerging research suggests that GLP-1 receptor agonists may possess anti-inflammatory properties

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That sounds modest, but it adds up