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demonstrated that human physiological concentrations of UA modulate the activity of SOD1 and SOD3 by preventing their inactivation by hydrogen peroxide (H 2 O 2 ) [37]

In A549 lung epithelial cells stimulated with lipopolysaccharide (LPS), quercetin reduced pro-inflammatory cytokines (TNF-, IL-1, IL-6), suppressed NF-B nuclear translocation, and downregulated NOX2 expressiona major ROS-generating enzymeat both mRNA and protein levels [66]

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Yet, when plant cells are damaged, myrosinase is released and comes in contact with glucosinolates, catalyzing their conversion into highly reactive metabolites that impart a pungent aroma and spicy (some say bitter) taste