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Synapse 75:e22221 Khan T, Waseem R, Zehra Z, Aiman A, Bhardwaj P, Ansari J et al (2022) Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches

Inhibition of lipid synthase activity: AOD 9604 reduces the activities of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreases de novo synthesis of fatty acids

This means that these patients did not achieve enough weight loss to provide them benefit in risk reduction for obesity associated conditions like diabetes and heart disease, while using [a] GLP-1 therapy alone