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Specifically, the synergistic action of metformin and simvastatin reshaped glioma metabolism, curbed malignant proliferation, promoted apoptosis, and demonstrated superior anti-tumor effects both in vitro and in vivo compared to individual administration of metformin or simvastatin

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Contrary to this is the experience of two patients (the first one with a very low Bell score of 20 at the start of SSRI treatment) who discontinued the SSRI after 8 months and a year, respectively, because they felt completely healthy for 2 and 7 months, respectively

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