The patent document is very extensive, containing synthesis examples of more than 3,000 cyclic peptides and detailing the Kd values for KRAS, NRAS, HRAS, as well as the inhibitory IC50 values on NCI-1441 cells
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The overall incidence of acute pancreatitis in tirzepatide clinical trials was low, and many patients who developed pancreatitis had identifiable alternative risk factors such as gallstones, alcohol use, or hypertriglyceridemia
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