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Invalidation of Gstp1/2 impairs hepatocyte proliferation In WT mice, the percentage of 5-bromo-2-deoxyuridine (BrdU)-positive hepatocytes increased at 40 h to reach a peak 48 h after PH

These findings suggest that CIH may directly or indirectly impair the secretory function of the HPG axis via oxidative stress and inflammatory mechanisms, ultimately leading to reduced levels of sex hormones

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GRd, glutathione reductase