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For nuclear and cytosolic targeting, we used histone H2B and a nuclear export sequence (NES), [3,40] respectively

The mitochondrial electron transport chain (ETC) and NADPH oxidase (NOX) are key sources of ROS in -cells, and their dysfunction further promotes oxidative stress

Clinical clues suggesting atypical TN include: weak or short-lived response to carbamazepine (Tegretol), younger age of onset, gradual onset instead of sudden attacks, persistent pain without pain-free intervals, pain beginning after dental procedures, pain provoked by chewing or talking, and absence of vascular compression on MRI

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