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For example, in patients afflicted with both rheumatoid arthritis and diabetes, IL-1R antagonist has demonstrated the capacity to enhance insulin sensitivity [108]

The THY1 + FLS are located in the sublining layer and have distinct functional properties, including perivascular, pro-inflammatory and DKK3 expression, each of which is associated with different aspects of synovial pathology

In December 2025, the World Health Organization issued Glucagon-like Peptide-1 (GLP-1) guidelines, conditionally recommending long-term use of these therapies for adults with obesity (Body Mass Index 30) combined with intensive behavioral support as part of a comprehensive strategy

We also need to differentiate the isolated effects of GLP-1 receptor agonists on male sexual health from the [effects from] weight loss. For more information: Adnan Ezici , MD, can be reached at [email protected].