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Deregulated activation of c-Met contributes to a few aspects of tumor progression, such as inducing neoplastic cells to disaggregate from the tumor mass, eroding basement membranes, infiltrating stromal matrices, and finally colonizing new tissues to form metastases ( Onset Chronic liver diseases such as cirrhosis and hepatitis B or C are triggers of HCC (Janevska et al., 2015)

Eur J Neurosci 2012;35:121829

Helps maintain skin barrier integrity and hydration

Release 286 , 6473 (2018)

In line with this finding, the ablation of Klotho specifically from the distal tubules certainly resulted in a hyperphosphatemic phenotype, but to a lesser degree than in systemic or whole nephron Klotho knockout models (25)