Women with PMOS frequently face a frustrating choice between treatments that target reproductive symptoms and those that address metabolic health, says Melanie Cree, MD, PhD, professor at CU Anschutz and first author of the report
However, if cold sensitivity is severe or accompanied by extreme fatigue, constipation, or unexplained weight gain, contact your GP to exclude thyroid dysfunction or other conditions
On the other hand, long-term changes to brain chemistry could also carry risks
Restoration of other normal functions of impaired GLP-1 signalling in the brain could have even more important effects
However, semaglutide may be more effective in some patients, especially those who need additional help with weight loss and blood sugar control