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One of the most common polymorphisms, affecting 20% to 50% of certain populations, is an absence of the GSTM1 gene ( GSTM1 -null), which decreases detoxification ability among other possible outcomes [36]

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35 In T2D, the NF-B pathway can be activated directly by excess metabolites and multiple inflammatory factors

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Figure 6 From our RNAseq analysis, we noted that many of the upregulated genes in the glutathione biosynthesis pathway (including Gclc and Gclm ) are canonical targets of the transcription factor NRF2 (53, 54)

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