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Weight loss and maintenance are quite challenging, as the body resists weight loss and increases signals from the brain to increase appetite and preserve its original weight

(2) F Bes, W Hofman, J Schuur, and C Van Boxtel (1992) Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients

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(5.1) Hyperglycemia or hypoglycemia with changes in insulin regimen: Make changes to a patients insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring