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According to research findings, cancer-related fatalities exceeding 90% can be attributed to the development of resistance to conventional chemotherapeutic treatment [27]

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Although most studies have focused on bacterial changes such as increased Streptococcus and Veillonella and decreased Faecalibacterium 63,64,65,66 , fungal involvement is supported by clinical observations of severe fungal infections in PSC patients 67,68 and serological evidence such as elevated ASCA in PSC populations 69

One could therefore argue that outcome-relevant GPx3 optimization could not be achieved due to the dosing regimen of the SUSTAIN CSX trial: the first selenium dose was administered shortly prior to CPB and the inflammatory insult, leaving little time for selenoprotein biosynthesis and tissue protection

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