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For patients with coexisting depression and obesity, naltrexone/bupropion can be considered first-line pharmacotherapy due to the antidepressant properties of bupropion, which functions as a noradrenalin and dopamine reuptake inhibitor (119)

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What they found through their research is that a population of neurons in the hindbrain [the lower part of the brain that connects it to the spinal cord] seem to play a key role in mediating the vast majority of the appetite suppressant and weight loss effects of the GLP-1 drug