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In the setting of widespread availability of excess calories and more sedentary lifestyles 2,3,4,5 as exists in much of the modern worldmechanisms that reduce muscle mass to conserve energy are counter-productive, and unfortunately result in higher fat deposition and obesity, and can exacerbate the risk of sarcopenia 6

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These drugs have different properties, Fatima Cody Stanford, an obesity-medicine physician at Massachusetts General Hospital and Harvard Medical School, told me