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A heat map of this data was generated using only the genera and metabolites that had previously demonstrated significant main effects of treatment group (Fig

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doi: 10.1111/acel.12527 8 Argueti-OstrovskyS.BarelS.KahnJ.IsraelsonA

An 8-week regimen of treadmill exercise leads to elevated serum lactate concentrations in ApoE / mice fed with HFD, activated the lactylation modification of Mecp2 at lysine 271 in aortic ECs, and subsequently suppressed the expression of the epidermal growth factor receptor (Egfr) ligand epiregulin (Ereg)