Dysregulation of adipokines significantly contributes to insulin resistance in T2DM
Pictured: Novo Nordisks office in California/iStock, hapabapa Novo Nordisk is temporarily reducing the supply of its diabetes treatment Victoza (liraglutide) in order to boost the production of its newer-generation type 2 diabetes drug Ozempic (semaglutide), according to an official communication from the company and the European Medicines Association
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In a diabetic nephropathy mouse model overexpressing the receptor for advanced glycation end products (RAGE) and an AGE-induced endothelial-macrophage co-culture injury model, catalpol regulates the RAGE/Ras homolog gene family member A (RhoA)/Rho-associated kinase (ROCK) signaling pathway, interferes with the interaction between macrophages and endothelial cells, reduces endothelial injury and chemokine secretion, inhibits macrophage migration, and restores the M1/M2 phenotypic balance, improving the pathological damage in diabetic nephropathy (Shu, 2021
