They may be used alone or synergistically with antifungals to alter gene expression related to adhesion, mycelial or biofilm formation, reduce extracellular polysaccharides, decrease surface hydrophobicity, or inhibit efflux pumps
The sensitivity of the quantification is high: 0.35 M for NAD + and NADP + , 0.28 M for NADH and NADPH, 72 M for the GSH pool and 10 M for GSSG (Supplementary Figure 1s)
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High-fat or high-sugar meals whilst not contraindicated, these may worsen gastrointestinal side effects, particularly during the dose escalation phase