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These systems allow targeted delivery of therapeutic nucleic acids, such as GPX4 mRNA to enhance antioxidant capacity or ACSL4-siRNA to limit peroxidation-prone lipid pools (164), enabling cell-type-specific suppression of ferroptosis

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Research published in The AAPS Journal confirms subcutaneous injections bypass enzymatic degradation and first-pass metabolism, resulting in higher systemic exposure and tighter control over therapeutic concentrations