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doi: 10.1210/mend-4-6-899
The gut-skin axis is a well-documented connection
But the drug is expensive, costing about $400 per injection
There is another bioflavonoid called luteolin that acts similarly and is very effective at 100 milligrams a day
Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney
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