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9 In response to energy scarcity, 5AMP accumulation activates the AMPK pathway, increasing phosphoinositide-dependent kinase-2 (PDK2) activity and GLUT1/4 expression to increase glycolysis

Pharmacodynamics: The observed pharmacodynamic effects in animal models often outlast measurable systemic exposure, suggesting mechanisms that include local tissue modulation, induction of growthfactor expression, and initiation of reparative cascades rather than sustained receptor occupancy requiring prolonged systemic presence