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PMID 28660890

Test results showed that the oral administration of PNE mediated a decrease in the abundance of Streptococcus intestinalis and an increase in the transgenic metabolite l-arginine, which further inhibited osteoblasts and enhanced osteoclasts through the gutbone axis, exerting a significant anti-osteoporotic effect

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Tips for Minimizing Side Effects Start Slowly : Your provider will often begin with a lower dose to allow your body to adjust