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51 In these studies, it has been reported that gallbladder stones and biliary tract diseases are more common in patients using GLP-1 RAs compared with placebo

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[20] [9] If severe abdominal pain develops during GLP-1 agonist treatmentparticularly if it persists for several hours or is accompanied by repeated vomitingpatients should stop taking the medication and seek immediate medical assessment

The experimental treatments and sampling timeline are elucidated in Figure 1

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