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Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (128)

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It is now needed to study the impact of these modifications on protein activity

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SPECIFICATIONS Specifications Glutathione peroxidase 4 (GPX4) C 23 H 21 CIN 2 O 5 40 mg/ml in DMSO, insoluble in water or ethanol 10 mM - 10 M Negative (tested using EndotoxDetect assay) Ferroptosis inhibition in cellular assay Ferroptosis inhibition Each lot is functionally tested and validated