semaglutide arrhythmia and AFib: Heart Safety for Weight Loss For patients with obesity and

Additional significant risks include: Gallbladder disease : GLP-1 receptor agonists are associated with increased risk of gallstones and cholecystitis Acute kidney injury : Particularly in the context of severe gastrointestinal side effects causing dehydration Pancreatitis : A rare but serious adverse effect that requires immediate discontinuation of treatment if suspected Nutritional considerations are paramount

F.OrskovC.HolstJ

Using propensity matching, the researchers compared 2,894 patients taking a GLP-1 receptor agonist at baseline with 2,894 patients not taking one at baseline

7 , e142 (2016)

In cases of early dementia or AD, GLP-1RA treatment protected metabolism and network connections in the brain, but did not significantly alter biomarkers associated with -amyloid or tau protein