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Therefore, advanced neuronal tracing methods, optogenetic approaches, and high-resolution electrophysiological mapping are increasingly necessary to clarify functional connectivity and downstream signaling integration

George Tidmarsh, director of the FDA's Center for Drug Evaluation and Research, said

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This link is believed to be primarily mediated by the metabolic, vascular, and inflammatory pathways associated with diabetes, which contribute to the pathogenesis of neurodegeneration

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