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In recent years, numerous prospective longitudinal studies, observational clinical and mechanistic studies, meta-analyses, Mendelian randomization studies and intervention trials with UA-lowering therapies have further strengthen the evidence linking elevated UA level with CVD and CVD-related mortality, albeit without offering enough evidence to support a causal relationship

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1 Introd uc tion Inflammatory bowel disease (IBD) comprises chronic inflammatory disorders of the gastrointestinal tract, primarily Crohns disease (CD) and ulcerative colitis (UC)

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