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Additionally, Fe2+ binds to the N-terminal domain of A, destabilizing its helical structure and promoting peptide aggregation by enhancing peptide-peptide interactions (37)

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In the Val-HeFT trial, 9.1% of patients with a baseline EF 40% after one year 1

These measurements were made while the patients were still exposed to the GLP1RAs, and thus were most likely attributable to an acute stimulation of insulin secretion by the drug