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Western blot (WB) results revealed a significant increase in the expression of Ki-67 and Lamin B, while the protein levels of P21, P16, and -H2AX decreased following FOXO4-DRI treatment (Figure 4A)

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doi: 10.1016/j.jri.2007.03.008 10

T lymphocytes in individuals suffering from chronic obstructive pulmonary disease (COPD) have been found to be immunodeficient, with an increased functional exhaustion of T cells that express PD-1, a negative co-stimulatory molecule linked to impaired immune responses [166]

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