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+ Muscle loss is a real concern with any caloric restriction

Side effects and safety comparison Greater efficacy often comes with greater side effects

In the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1 mg for type 2 diabetes, nausea rates were 17-22% for tirzepatide across all three dose levels (5 mg, 10 mg, and 15 mg) versus 18% for semaglutide 1 mg

But certain signs could mean a bigger problem or an infection, as described in clinical safety guidelines for injection site monitoring

However, if you are already taking insulin or other antidiabetic medicines, your prescriber will need to adjust your diabetes treatment to reduce the risk of hypoglycaemia