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A multicenter, open-label prospective study by Shalita et al 41 evaluating the effect of a supplement NicAzel (nicotinamide, azelaic acid, zinc oxide, pyridoxine, copper, and folic acid) found a significant reduction in lesion count when given in addition to the patients acne regimen

Collectively they represent a depth of preclinical discovery activity in China that has no parallel in the U.S., Europe, or Korea

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