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Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans

we're delving into cellular energy, mitochondrial function, and overall systemic well-being

[PubMed] He J, Hu B, Shi X, Weidert ER, Lu P, Xu M, Huang M, Kelley EE, Xie W (2013) Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3

It is not recommended to use GLP-1 therapies like Trulicity and Victoza (liraglutide) if there is a family history of medullary cell carcinoma of the thyroid or Multiple Endocrine Neoplasia Type 2 (MEN 2)

Still, the authors caution that the results do not establish causation