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How The Body Handles Excess B12 As mentioned above, vitamin B12 is a water-soluble vitamin

Excess B12 does not generally cause direct harm to the kidneys or liver in people with healthy organs

Niacinamide (B), like niacin, has several notable interactions

Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis

[20] For nutritional deficiency without intrinsic-factor loss, shorter courses-such as 30-100 mcg intramuscularly daily for five to ten days followed by 100-200 mcg monthly-are often sufficient