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Animal studies comparing local versus systemic BPC-157 administration found no significant difference in healing outcomesthe peptide circulates effectively and accumulates at injury sites regardless of injection location

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Coagulation dysfunction is prevalent during sepsis, with the pathogenesis primarily involving the release of numerous inflammatory mediators, endothelial cell injury, activation of the extrinsic coagulation pathway, and suppression of anticoagulant and fibrinolytic systems (129)