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This enzymatic barrier explains why many patients report minimal clinical benefit from standard oral supplements

Clinical Studies Despite increasing preclinical evidences of the involvement of seleno-GPxs in cellular radiosensitivity, there is no such clinical trial reported yet that focused solely on examining the effects of seleno-GPxs for modulating the radiation response of normal and/or tumor tissues

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In vitro experiments demonstrated that cancer-associated adipocytes upregulate the hexosamine biosynthetic pathway (HBP), leading to O-GlcNAcylation and stabilization of the YAP protein