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Hesselink, M
Other risks linked to Contrave include seizures, liver problems, angle-closure glaucoma (a serious eye condition), and increases in blood pressure or heart rate
Additionally, patients with MS show a selective downregulation of the protein annexin A1 in the plasma and cerebral microvessel endothelia and annexin A1 knockout mice have increased BBB permeability [133]
Meanwhile, new competitive threats continued to surface: in 2025, Lilly unveiled impressive results for an oral GLP-1 pill (orforglipron) that in trials matched injectable Ozempic's efficacy, news that instantly added ~$100 billion to Lilly's market cap
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