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Such risk factors include early treatment phase, persistent gastrointestinal symptoms such as nausea or vomiting, and comorbid conditions such as diabetic gastroparesis or Parkinsons disease

This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule

Inflammation increases the bioactive molecules in the tumor microenvironment, such as cytokines, chemokines, growth factors, and matrix-modifying enzymes (e.g., MMPs), which in turn raises the risk of cancer development [80]

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The breakdown by weight loss achievement is striking