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Mechanism of Action GLP-1R agonism enhances glucose-dependent insulin secretion, suppresses glucagon, delays gastric emptying, and reduces appetite GIPR agonism amplifies insulin secretion additively

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They stimulate glucose-dependent insulin release from the pancreas, slow gastric emptying (prolonging a feeling of satiety), inhibit post-meal glucagon release (glucagon stimulates liver and muscle cells to convert stored glycogen back into glucose, raising blood glucose levels) and reduce the desire for food intake

The spray pump unit must be fully primed (see DOSAGE AND ADMINISTRATION ) prior to initial use

Temperature plays a key role in preserving their structure and function