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Attend all scheduled appointments and don't hesitate to contact your GP or diabetes nurse between visits if you experience: Severe or persistent nausea/vomiting preventing adequate nutrition or hydration Signs of pancreatitis (severe, persistent abdominal pain radiating to the back) Symptoms of gallbladder problems (right upper abdominal pain, particularly after eating) Unexplained visual changes Signs of hypoglycaemia if taking other diabetes medications Realistic goal-setting improves long-term success

This baseline allows objective comparison at three, six, and twelve months

Donoughe, S

and the PEGylated agonist NLY01, which on this account does not effectively reach the brain despite being engineered for penetrance, was negative in a Phase 2 Parkinsons trial [12,13]