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Machado ND, Heather LC, Harris AL, Higgins GS

Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021) A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

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It typically peaks during the first one to two weeks at each new dose level and gradually diminishes as the body adapts

Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]